Circhomer1
WebCircHomer1_a was significantly up-regulated in primary hippocampal neurons (Figure 4D, E) and hippocampal slices (Figure 4F). Taken together, these data show that circRNA expression levels are regulated by neural plasticity, suggesting their importance in regulating synaptic transmission and/or local translation. WebJan 16, 2024 · The second dataset replicated those findings: 28 circular RNAs, including circHOMER1, were significantly associated with all three traits. Together, these findings suggest there is a significant association between the expression of certain circular RNAs like circHOMER1 in the brain and Alzheimer’s traits.
Circhomer1
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WebThe results showed that circHOMER1 inhibited adipogenic differentiation of porcine preadipocytes and suppressed adipogenesis in mice. Dual-luciferase reporter gene, RIP, and pull-down assays demonstrated that miR-23b directly bound to circHOMER1 and the 3'-UTR of SIRT1. Rescue experiments further illustrated the regulatory relationship among ... WebCircHOMER1 was highly expressed in HG-induced HMCs and DN patients. Downregulation of circHOMER1 suppressed oxidative stress, inflammation and ECM deposition in HMCs induced by HG. In terms of mechanism, circHOMER1 could sponge miR-137 to regulate SOX6. Function assays showed that miR-137 inhibitor or SOX6 overexpression revoked …
WebOct 1, 2024 · Downregulation of circHOMER1 suppressed oxidative stress, inflammation and ECM deposition in HMCs induced by HG. In terms of mechanism, circHOMER1 could sponge miR-137 to regulate SOX6. Function assays showed that miR-137 inhibitor or SOX6 overexpression revoked the negative regulation of circHOMER1 knockdown on HG … WebNational Center for Biotechnology Information
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WebDec 7, 2024 · Lastly, we demonstrate that circHomer1 is an experience-dependent circRNA that is significantly altered during chance reversal learning and that variability in its baseline expression within the OFC is significantly inversely correlated to behavioral performance during chance reversal learning. Taken together our data provide novel mechanistic ...
WebResearch assistant in Dr. Janet Neisewander's neuroscience of substance abuse lab at Arizona State University. I lead and managed a project studying the effects of the circRNA circHomer1 on ... no right 意味WebJan 18, 2024 · Importantly, double circHomer1 and Homer1b in vivo co-KD results in a complete rescue in circHomer1-associated alterations in both chance reversal learning and synaptic gene expression. Lastly, we uncover an RNA-binding protein that can directly bind to circHomer1 and promote its biogenesis. Taken together, our data provide … how to remove mold from laundry machineWebJan 18, 2024 · Importantly, double circHomer1 and Homer1b in vivo co-KD results in a complete rescue in circHomer1-associated alterations in both chance reversal learning and synaptic gene expression. Lastly, we ... no rigs connected yet nicehashWebJan 18, 2024 · In order to examine whether alterations in circHomer1 are associated with the expression of specific HOMER1 mRNA isoforms, we used isoform-specific quantitative real-time PCR in postmortem samples from the OFC of subjects with BD (n = 30), SCZ (n = 32), and unaffected controls (n = 33) derived from the Stanley Medical Research Institute … norihiro yamaguchi oxford economicsWebJul 27, 2024 · Knockdown of circHomer1 ameliorates neurotoxicity induced by METH and partially down-regulated Bbc3 expression. And that, it was possible that Bbc3 functioned as one underlying target of circHomer1 to promote the METH lethal process. Besides, there are highly correlation among circHomer1, Bbc3 and addictive behaviors, respectively. how to remove mold from lawnWeb(2)circHomer1的功能分析结果:筛选表达差异显著的circHomer1进行后续研究,发现METH损伤后,circHomer1在原代脑皮层神经元与HT-22细胞中表达均显著上调。对circHomer1的PCR产物进行分析,可以发现其中包含反向剪接位点,并且在RNase R消化实验中发现circHomer1具有较强的稳定性。 no right wayWebWe demonstrate that circHomer1 is an experience-dependent circRNA that is significantly altered during chance reversal learning and that variability in its baseline expression is significantly ... how to remove mold from laundry