Kabachnik–fields reaction
Webb28 maj 2024 · Postpolymerization modification and step-growth polymerization reactions based on MCRs and sequential reactions such as the Kabachnik–Fields three … WebbAbstract. A simple, efficient and eco-friendly protocol has been described for the synthesis of α-aminophosphonates via Kabachnik-Fields reaction, catalyzed by H 6 P 2 W 18 O 62 ·14H 2 O as a reusable catalyst. The reaction was realized by condensation of amino acids, various aromatic aldehydes and triethylphosphite under solvent-free conditions, …
Kabachnik–fields reaction
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Webb12 apr. 2024 · Bioisosteres of amino acids called α-aminophosphonates have a variety of therapeutic properties. A set of procedures involving amine, aldehydes and triethylphosphite have been utilized to synthesize these compounds in presence of Lewis acid catalysts such as lithium perchlorate via the Kabachnik-Fields reaction. WebbAbstract. The review discusses recent achievements in the development of more ecofriendly and economically viable processes for the synthesis of biologically potent α-aminophosphonates via Kabachnik-Fields reaction by three-component coupling of carbonyl, amine and hydrophosphoryl compounds.
WebbThe review discusses recent achievements in the development of more ecofriendly and economically viable processes for the synthesis of biologically potent α … WebbThe Kabachnik-Fields reaction represents undoubtedly the most straightforward approach to α-aminophosphonates starting from simple aldehydes, amines and …
Webb4a obtained in the course of the Kabachnik–Fields reaction (Scheme 1). It is considered of interest to compare the rates of the Kabachnik–Fields and Pudovik reactions on the basis of interactions de-picted in Schemes 1 and 2. It was found that α-aminophosphonates E,Z-4a in the Pudovik reaction formsmoreslowly. The α,β … Webb19 mars 2024 · The Kabachnik-Fields reaction, a one-pot synthesis of α-amino phosphonates via a three-component coupling of an aldehyde (or ketone), an amine, …
Webb25 apr. 2024 · In this paper, the microwave (MW)-assisted catalyst-free and mostly solvent-free Kabachnik-Fields reaction of amino alcohols, paraformaldehyde, and various >P(O)H reagents (dialkyl phosphites, ethyl phenyl-H-phosphinate, and secondary phosphine oxides) is reported.The synthesis of N-2-hydroxyethyl-α-aminophosphonate …
Webb16 feb. 2007 · Commercially available magnesium perchlorate is reported as an extremely efficient catalyst for the synthesis of alpha-aminophosphonates. A three-component … infj countriesWebb12 mars 2024 · The Povarov Reaction: A Versatile Method to Synthesize Tetrahydroquinolines, Quinolines and Julolidines. Synthesis 2024, 54 (14) ... Fei Liu, Guo-Yan Zhao, Song Wang, Yu-Bin Dong. Synthesis of covalent organic frameworks via Kabachnik-Fields reaction for water treatment. Journal of Hazardous Materials 2024, … infj dangerous personalityWebb16 dec. 2024 · This research exploits a biocompatible magnetic self-healing hydrogel with well-dispersed IONPs, demonstrating the value of the KF reaction in the development … infj drug addictionWebb15 apr. 2014 · A Kabachnik-Fields postpolymerization modification reaction (KF-PMR) was conducted on poly(4-vinyl benzaldehyde) (poly(St-CHO)) with amines and … infj characteristics listWebb21 maj 2013 · The synthesis of new α-aminophosphonic acid esters was achieved in high yields through a one-pot three-component reaction process, a Kabachnik-Fields reaction. It involves the reactions among substituted anilines, substituted aromatic aldehydes, and dialkyl phosphites in dry toluene at reflux temperature, in the presence … infj electronics engineering technologyWebb4 juni 2024 · The Kabachnik–Fields reaction may take place according to two routes. The first possibility is that the dialkyl phosphite adds to the C O group of the … infj dating adviceWebbThe review discusses the classical version of the Kabachnik–Fields reaction, its modifications with the use of phosphorus chlorides, neutral esters and inorganic phosphorus acids, as well as chemical processes simulating separate steps of the reaction, viz., hydrophosphorylation of imines and amination of α-hydroxy phosphonates. infj dnd race